Gillet, L C J; Schärer, O D (2002). Preparation of C8-amine and acetylamine adducts of 2'-deoxyguanosine suitably protected for DNA synthesis. Organic Letters, 4(24):4205-4208.
[reaction: see text] C8-Amine and acetylamine adducts of 2'-deoxyguanosine were synthesized. Our approach provides solutions for the coupling of aromatic amines to a protected 8-bromo-2'-deoxyguanosine derivative, for the selective acetylation of the coupled adduct at N(8) and for a protecting group scheme preserving the integrity of the base-labile N(8) acetyl group during DNA synthesis.
[reaction: see text] C8-Amine and acetylamine adducts of 2'-deoxyguanosine were synthesized. Our approach provides solutions for the coupling of aromatic amines to a protected 8-bromo-2'-deoxyguanosine derivative, for the selective acetylation of the coupled adduct at N(8) and for a protecting group scheme preserving the integrity of the base-labile N(8) acetyl group during DNA synthesis.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > Institute of Molecular Cancer Research
07 Faculty of Science > Institute of Molecular Cancer Research |
| Dewey Decimal Classification: | 570 Life sciences; biology |
| Scopus Subject Areas: | Life Sciences > Biochemistry
Physical Sciences > Physical and Theoretical Chemistry Physical Sciences > Organic Chemistry |
| Language: | English |
| Date: | 2002 |
| Deposited On: | 09 Jul 2010 09:10 |
| Last Modified: | 23 Jan 2022 16:10 |
| Publisher: | American Chemical Society |
| ISSN: | 1523-7052 |
| OA Status: | Closed |
| Publisher DOI: | https://doi.org/10.1021/ol026474f |
| PubMed ID: | 12443059 |
Gillet, L C J