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Güthlein, C; Wanner, R M; Sander, P; Böttger, E C; Springer, B (2008). A mycobacterial smc null mutant is proficient in DNA repair and long-term survival. Journal of Bacteriology, 190(1):452-456.
SMC (structural maintenance of chromosomes) proteins play fundamental roles in various aspects of chromosome organization and dynamics, including repair of DNA damage. Mutant strains of Mycobacterium smegmatis and Mycobacterium tuberculosis defective in SMC were constructed. Surprisingly, inactivation of smc did not result in recognizable phenotypes in hallmark assays characteristic for the function of these genes. This is in contrast to data for smc null mutants in other species.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > Institute of Medical Microbiology |
| Dewey Decimal Classification: | 570 Life sciences; biology
610 Medicine & health |
| Scopus Subject Areas: | Life Sciences > Microbiology
Life Sciences > Molecular Biology |
| Language: | English |
| Date: | January 2008 |
| Deposited On: | 09 Sep 2008 11:32 |
| Last Modified: | 01 Sep 2024 01:38 |
| Publisher: | American Society for Microbiology |
| ISSN: | 0021-9193 |
| Additional Information: | Copyright: American Society for Microbiology |
| OA Status: | Hybrid |
| Free access at: | PubMed ID. An embargo period may apply. |
| Publisher DOI: | https://doi.org/10.1128/JB.01315-07 |
| PubMed ID: | 17981972 |
Güthlein, C