Header

UZH-Logo

Maintenance Infos

Irinotecan and mismatch repair deficiency


Power, D G; Feilchenfeldt, J (2010). Irinotecan and mismatch repair deficiency. Annals of Oncology, 21(2):432-433.

Abstract

e read the recent publications of Ychou et al. [1, 2] on ‘adjuvant’ irinotecan-based chemotherapy in high-risk localized colorectal cancer (CRC) and after resection of liver-confined metastatic disease with great interest. In contrast to the improved outcome provided by oxaliplatin-based adjuvant treatment of early-stage disease, there is now a body of evidence showing that the addition of irinotecan to 5-fluorouracil (5-FU)/Leucovorin does not provide a benefit in this setting [1, 3]. The authors are to be congratulated for reporting the largest randomized trial of adjuvant treatment after resected colorectal liver metastases. Such trials have been historically difficult to accrue and it has …

Abstract

e read the recent publications of Ychou et al. [1, 2] on ‘adjuvant’ irinotecan-based chemotherapy in high-risk localized colorectal cancer (CRC) and after resection of liver-confined metastatic disease with great interest. In contrast to the improved outcome provided by oxaliplatin-based adjuvant treatment of early-stage disease, there is now a body of evidence showing that the addition of irinotecan to 5-fluorouracil (5-FU)/Leucovorin does not provide a benefit in this setting [1, 3]. The authors are to be congratulated for reporting the largest randomized trial of adjuvant treatment after resected colorectal liver metastases. Such trials have been historically difficult to accrue and it has …

Statistics

Citations

Altmetrics

Downloads

25 downloads since deposited on 06 Jul 2010
14 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Oncology and Hematology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Hematology
Health Sciences > Oncology
Date:February 2010
Deposited On:06 Jul 2010 21:53
Last Modified:29 Jul 2020 22:38
Publisher:Oxford University Press
ISSN:0923-7534
OA Status:Hybrid
Publisher DOI:https://doi.org/10.1093/annonc/mdp550
PubMed ID:19940003

Download

Hybrid Open Access

Download PDF  'Irinotecan and mismatch repair deficiency'.
Preview
Content: Published Version
Language: English
Filetype: PDF (Nationallizenz 142-005)
Size: 36kB
View at publisher