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Irinotecan and mismatch repair deficiency


Power, D G; Feilchenfeldt, J (2010). Irinotecan and mismatch repair deficiency. Annals of Oncology, 21(2):432-433.

Abstract

e read the recent publications of Ychou et al. [1, 2] on ‘adjuvant’ irinotecan-based chemotherapy in high-risk localized colorectal cancer (CRC) and after resection of liver-confined metastatic disease with great interest. In contrast to the improved outcome provided by oxaliplatin-based adjuvant treatment of early-stage disease, there is now a body of evidence showing that the addition of irinotecan to 5-fluorouracil (5-FU)/Leucovorin does not provide a benefit in this setting [1, 3]. The authors are to be congratulated for reporting the largest randomized trial of adjuvant treatment after resected colorectal liver metastases. Such trials have been historically difficult to accrue and it has …

Abstract

e read the recent publications of Ychou et al. [1, 2] on ‘adjuvant’ irinotecan-based chemotherapy in high-risk localized colorectal cancer (CRC) and after resection of liver-confined metastatic disease with great interest. In contrast to the improved outcome provided by oxaliplatin-based adjuvant treatment of early-stage disease, there is now a body of evidence showing that the addition of irinotecan to 5-fluorouracil (5-FU)/Leucovorin does not provide a benefit in this setting [1, 3]. The authors are to be congratulated for reporting the largest randomized trial of adjuvant treatment after resected colorectal liver metastases. Such trials have been historically difficult to accrue and it has …

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Oncology
Dewey Decimal Classification:610 Medicine & health
Date:February 2010
Deposited On:06 Jul 2010 21:53
Last Modified:29 Aug 2018 17:38
Publisher:Oxford University Press
ISSN:0923-7534
OA Status:Green
Publisher DOI:https://doi.org/10.1093/annonc/mdp550
PubMed ID:19940003

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