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Urban, P L; Amantonico, A; Fagerer, S R; Gehrig, P; Zenobi, R (2010). Mass spectrometric method incorporating enzymatic amplification for attomole-level analysis of target metabolites in biological samples. Chemical Communications, 46(13):2212-2214.
We report a sensitive method for selective detection of target metabolites from the central metabolic pathway by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS), in which the MS signal is enhanced by up to three orders of magnitude in the course of in situ enzymatic amplification.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > Functional Genomics Center Zurich
08 Research Priority Programs > Systems Biology / Functional Genomics |
| Dewey Decimal Classification: | 570 Life sciences; biology
610 Medicine & health |
| Scopus Subject Areas: | Physical Sciences > Catalysis
Physical Sciences > Electronic, Optical and Magnetic Materials Physical Sciences > Ceramics and Composites Physical Sciences > General Chemistry Physical Sciences > Surfaces, Coatings and Films Physical Sciences > Metals and Alloys Physical Sciences > Materials Chemistry |
| Language: | English |
| Date: | 2010 |
| Deposited On: | 04 Nov 2010 16:04 |
| Last Modified: | 04 Mar 2025 02:39 |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 1359-7345 |
| OA Status: | Closed |
| Free access at: | Related URL. An embargo period may apply. |
| Publisher DOI: | https://doi.org/10.1039/b925433a |
| PubMed ID: | 20234909 |
Urban, P L