INTRODUCTION: Of the many different factors associated with an increased risk for oral squamous cell carcinoma (SCC), tobacco and alcohol seems to be the best studied. The aim of the current study was to evaluate the clinicopathologic characteristics of patients without the mentioned risk factors. Patients and Methods From 278 patients (159 male and 119 female patients) with oral SCC, 67 patients were without a history of tobacco or alcohol use. The minimum follow-up time was 12 months. RESULTS: Of the 67 patients, 45 (67.2%) were women and the mean age was 70 years. The most common tumor sites were mandibular alveolar ridge: 22 and maxilla: 18. Fifteen patients experienced a recurrence and 10 developed lymph node metastases during the follow-up period. CONCLUSION: The group of patients without tobacco and alcohol use tends to have a higher female portion, higher potion of patients being over 70 years and a higher number of oral maxillary SCC.