The new developments of the globalization process bring with them new responsibilities for the multinational corporation and its leaders. The aim of the paper was to identify those new responsibilities and to look at the changing role of leadership due to those responsibilities. This paper thereby acknowledges the need for a more descriptive and prescriptive social scientific approach by aiming for an understanding of what will be called globally responsible leadership. The article starts with pointing to the changing role of leadership due to new ecological, societal and business obligations leaders in organizations are facing. The following literature review of leadership theories shows that there is no theory that can fully address the new developments. Thus, it is developed a new framework of globally responsible leadership that encompasses those new obligations and that exemplifies the personal preconditions of globally responsible leaders. It is therefore drawn upon theories of responsibility form the philosophy of law and further disciplines. The elements of the framework of globally responsible leadership are explained and suggestions are made of how to empirically capture globally responsible leadership behaviour. At the end, the article points to future research directions.