We describe a new cable-free, non-telemetric method for synchronized electrophysiological and videorecordings of seizure activity in freely moving mice. The electrophysiological recordings were made bya head-mounted 4-channel data-logging device, allowing the mouse to move freely in its cage, and evento be moved from cage to cage under ongoing recording. Seizures were studied in Synapsin I/II doubleknock-out (SynDKO) mice, a genetically engineered mouse line that shows seizures upon daily handlingprocedures such as tail lifting during cage changes, much in resemblance to the more studied El mouse.
The ability to elicit seizures through daily handling in SynDKO mice undergoing electrophysiological recording is a significant improvement in comparison to the traditional cable-based set-up. Furthermore, with its four channels and a sample rate of up to 500 Hz, the data-logging device opens for more varied electrophysiological studies than other available cable-free systems.