Navigation auf zora.uzh.ch

Search ZORA

ZORA (Zurich Open Repository and Archive)

Pharmacological approaches to improve endothelial repair mechanisms

Besler, C; Doerries, C; Giannotti, G; Luescher, T F; Landmesser, U (2008). Pharmacological approaches to improve endothelial repair mechanisms. Expert Review of Cardiovascular Therapy, 6(8):1071-1082.

Abstract

Endothelial injury is thought to play a pivotal role in the development and progression of vascular diseases such as atherosclerosis, hypertension and restenosis, and their complications, including myocardial infarction or stroke. Accumulating evidence suggests that bone marrow-derived endothelial progenitor cells (EPCs) promote endothelial repair and contribute to ischemia-induced neovascularization. Coronary artery disease and its risk factors, such as diabetes, hypercholesterolemia, hypertension and smoking, are associated with a reduced number and impaired functional activity of circulating EPCs. Moreover, first data suggest that reduced EPC levels are associated with endothelial dysfunction and an increased risk of cardiovascular events, compatible with the concept that impaired EPC-mediated vascular repair promotes progression of vascular disease.
In the present review article we summarize recent data on the effects of pharmacological agents on mobilization and functional activity of EPCs. In particular, several experimental and clinical studies have suggested that statins, angiotensin-converting enzyme inhibitors, angiotensin II type 1 receptor blocker, PPAR-gamma agonists and erythropoietin increase the number and functional activity of EPCs. The underlying mechanisms remain largely to be defined; however, they likely include activation of the PI3-kinase/Akt pathway and endothelial nitric oxide synthase, as well as inhibition of NAD(P)H oxidase activity of progenitor cells.

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Zurich Center for Integrative Human Physiology (ZIHP)
04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Health Sciences > Internal Medicine
Health Sciences > Cardiology and Cardiovascular Medicine
Language:English
Date:September 2008
Deposited On:20 Oct 2008 13:03
Last Modified:02 Oct 2024 03:44
Publisher:Expert Reviews (formerly Future Drugs)
ISSN:1477-9072
Additional Information:Full text at http://www.expert-reviews.com/doi/abs/10.1586/14779072.6.8.1071?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dncbi.nlm.nih.gov
OA Status:Closed
Publisher DOI:https://doi.org/10.1586/14779072.6.8.1071
PubMed ID:18793110

Metadata Export

Statistics

Citations

Dimensions.ai Metrics

Altmetrics

Downloads

7 downloads since deposited on 20 Oct 2008
0 downloads since 12 months
Detailed statistics

Authors, Affiliations, Collaborations

Similar Publications