Navigation auf zora.uzh.ch

Search ZORA

ZORA (Zurich Open Repository and Archive)

Locomotion in Parkinson's disease: neuronal coupling of upper and lower limbs

Dietz, V; Michel, J (2008). Locomotion in Parkinson's disease: neuronal coupling of upper and lower limbs. Brain: A Journal of Neurology, 131(12):3421-3431.

Abstract

Quadrupedal limb coordination during human walking was recently shown to be upregulated during obstacle stepping. An anticipatory activity of coupled cervico-thoraco-lumbar interneuronal circuits is followed by an appropriate executory activation of leg and arm muscles during task performance. This mechanism was studied in subjects with Parkinson's disease and age-matched controls walking on a treadmill with a randomly approaching obstacle. Spinal reflex (SR) responses, evoked by tibial nerve stimulation during mid-stance, were present in all arm and leg muscles investigated. They were larger before execution of obstacle avoidance compared with normal steps in both subject groups. The performance of obstacle stepping was slightly worse in Parkinson's disease than in control subjects. The anticipatory SR in the arm muscles prior to normal and obstacle steps was larger in Parkinson's disease compared with age-matched subjects, but smaller in the tibialis anterior. The arm and leg muscle activation was stronger during obstacle compared with normal swing but did not differ between Parkinson's disease and age-matched subjects. These observations indicate that quadrupedal limb coordination is basically preserved in Parkinson's disease subjects. Our data are consistent with the proposal that in Parkinson's disease subjects the enhanced anticipatory spinal neuronal activity (reflected in the SR) in the arm muscles is required to achieve an appropriate muscle activation for the automatic control of body equilibrium during the performance of the task. In the tibialis anterior the SR is attenuated presumably because of a stronger voluntary (i.e. cortical) control of leg movements.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Balgrist University Hospital, Swiss Spinal Cord Injury Center
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Neurology (clinical)
Language:English
Date:2008
Deposited On:08 Jan 2009 15:58
Last Modified:01 Nov 2024 02:38
Publisher:Oxford University Press
ISSN:0006-8950
Additional Information:This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Brain following peer review. The definitive publisher-authenticated version: Brain. 2008 Dec;131(Pt 12):3421-31 is available online at: http://brain.oxfordjournals.org/cgi/reprint/131/12/3421
OA Status:Hybrid
Publisher DOI:https://doi.org/10.1093/brain/awn263
PubMed ID:18930965
Download PDF  'Locomotion in Parkinson's disease: neuronal coupling of upper and lower limbs'.
Preview
  • Content: Accepted Version
  • Language: English
Download PDF  'Locomotion in Parkinson's disease: neuronal coupling of upper and lower limbs'.
Preview
  • Content: Published Version
  • Language: English
  • Description: Nationallizenz 142-005

Metadata Export

Statistics

Citations

Dimensions.ai Metrics
28 citations in Web of Science®
34 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

165 downloads since deposited on 08 Jan 2009
15 downloads since 12 months
Detailed statistics

Authors, Affiliations, Collaborations

Similar Publications