Garuti, C; Tian, Y; Montosi, G; Sabelli, M; Corradini, E; Graf, R; Ventura, P; Vegetti, A; Clavien, P A; Pietrangelo, A (2010). Hepcidin expression does not rescue the iron-poor phenotype of Kupffer cells in Hfe-null mice after liver transplantation. Gastroenterology, 139(1):315-322.e1.
In Hfe(-/-) mice, transplantation of livers from Hfe(+/+) mice reversed the iron-loading phenotype associated with hemochromatosis (regardless of Hfe expression in intestine). However, KCs still had low levels of iron that were not affected by hepatic hepcidin expression. These findings indicate an independent, iron-modifying effect of HFE in KCs.
In Hfe(-/-) mice, transplantation of livers from Hfe(+/+) mice reversed the iron-loading phenotype associated with hemochromatosis (regardless of Hfe expression in intestine). However, KCs still had low levels of iron that were not affected by hepatic hepcidin expression. These findings indicate an independent, iron-modifying effect of HFE in KCs.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > University Hospital Zurich > Clinic for Visceral and Transplantation Surgery |
| Dewey Decimal Classification: | 610 Medicine & health |
| Scopus Subject Areas: | Health Sciences > Hepatology
Health Sciences > Gastroenterology |
| Language: | English |
| Date: | 2010 |
| Deposited On: | 14 Apr 2011 09:19 |
| Last Modified: | 23 Jan 2022 18:33 |
| Publisher: | Elsevier |
| ISSN: | 0016-5085 |
| OA Status: | Closed |
| Publisher DOI: | https://doi.org/10.1053/j.gastro.2010.03.043 |
| PubMed ID: | 20338170 |
Garuti, C