Li, L; Bimmler, D; Graf, R; Zhou, S; Sun, Z; Chen, J; Siech, M; Bachem, M G (2011). PSP/reg inhibits cultured pancreatic stellate cell and regulates MMP/ TIMP ratio. European Journal of Clinical Investigation, 41(2):151-158.
Our work describes a novel aspect that in vitro PSP/reg reduces PSC activity (proliferation and migration) and stimulates fibrolysis by increasing MMP/TIMP ratio. The findings suggest that PSP/reg might have a protective function in the repair phase of acute and chronic pancreatitis by promoting resolution of fibrosis. We highlight PSP/reg as an antifibrogenic protein in pancreatic injury.
Our work describes a novel aspect that in vitro PSP/reg reduces PSC activity (proliferation and migration) and stimulates fibrolysis by increasing MMP/TIMP ratio. The findings suggest that PSP/reg might have a protective function in the repair phase of acute and chronic pancreatitis by promoting resolution of fibrosis. We highlight PSP/reg as an antifibrogenic protein in pancreatic injury.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > University Hospital Zurich > Division of Surgical Research
04 Faculty of Medicine > University Hospital Zurich > Clinic for Visceral and Transplantation Surgery |
| Dewey Decimal Classification: | 610 Medicine & health |
| Scopus Subject Areas: | Life Sciences > Biochemistry
Life Sciences > Clinical Biochemistry |
| Language: | English |
| Date: | 2011 |
| Deposited On: | 14 Apr 2011 07:42 |
| Last Modified: | 23 Jan 2022 18:33 |
| Publisher: | Wiley-Blackwell |
| ISSN: | 0014-2972 |
| OA Status: | Closed |
| Publisher DOI: | https://doi.org/10.1111/j.1365-2362.2010.02390.x |
| PubMed ID: | 20860757 |
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Li, L