Imesch, P; Fink, D; Fedier, A (2010). Romidepsin reduces histone deacetylase activity, induces acetylation of histones, inhibits proliferation, and activates apoptosis in immortalized epithelial endometriotic cells. Fertility and Sterility, 94(7):2838-2842.
Romidepsin inhibited HDAC activity, produced acetylation of the histone proteins, up-regulated p21, and down-regulated cyclins B1 and D1, resulting in proliferation inhibition and apoptosis activation in 11z immortalized epithelial endometriotic cells. Our findings provide evidence that endometriotic cells are sensitive to the epigenetic effects of romidepsin and suggest that endometriosis may be therapeutically targeted by romidepsin.
Romidepsin inhibited HDAC activity, produced acetylation of the histone proteins, up-regulated p21, and down-regulated cyclins B1 and D1, resulting in proliferation inhibition and apoptosis activation in 11z immortalized epithelial endometriotic cells. Our findings provide evidence that endometriotic cells are sensitive to the epigenetic effects of romidepsin and suggest that endometriosis may be therapeutically targeted by romidepsin.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > University Hospital Zurich > Clinic for Gynecology |
| Dewey Decimal Classification: | 610 Medicine & health |
| Scopus Subject Areas: | Health Sciences > Reproductive Medicine
Health Sciences > Obstetrics and Gynecology |
| Language: | English |
| Date: | 2010 |
| Deposited On: | 16 Feb 2011 17:12 |
| Last Modified: | 28 Jun 2022 15:02 |
| Publisher: | Elsevier |
| ISSN: | 0015-0282 |
| OA Status: | Closed |
| Publisher DOI: | https://doi.org/10.1016/j.fertnstert.2010.04.052 |
| PubMed ID: | 20605144 |
Imesch, P