Header

UZH-Logo

Maintenance Infos

Defects of steroidogenesis


Biason-Lauber, A; Boscaro, M; Mantero, F; Balercia, G (2010). Defects of steroidogenesis. Journal of Endocrinological Investigation, 33(10):756-766.

Abstract

In the biosynthesis of steroid hormones the neutral lipid cholesterol, a normal constituent of lipid bilayers is transformed via a series of hydroxylation, oxidation, and reduction steps into a vast array of biologically active compounds: mineralocorticoids, glucocorticoids, and sex hormones. Glucocorticoids regulate many aspects of metabolism and immune function, whereas mineralocorticoids help maintain blood volume and control renal excretion of electrolytes. Sex hormones are essential for sex differentiation in male and support reproduction. They include androgens, estrogens, and progestins. A block in the pathway of steroid biosynthesis leads to the lack of hormones downstream and accumulation of the upstream compounds that can activate other members of the steroid receptor family. This review deals with the clinical consequences of these blocks.

Abstract

In the biosynthesis of steroid hormones the neutral lipid cholesterol, a normal constituent of lipid bilayers is transformed via a series of hydroxylation, oxidation, and reduction steps into a vast array of biologically active compounds: mineralocorticoids, glucocorticoids, and sex hormones. Glucocorticoids regulate many aspects of metabolism and immune function, whereas mineralocorticoids help maintain blood volume and control renal excretion of electrolytes. Sex hormones are essential for sex differentiation in male and support reproduction. They include androgens, estrogens, and progestins. A block in the pathway of steroid biosynthesis leads to the lack of hormones downstream and accumulation of the upstream compounds that can activate other members of the steroid receptor family. This review deals with the clinical consequences of these blocks.

Statistics

Citations

Dimensions.ai Metrics
7 citations in Web of Science®
9 citations in Scopus®
8 citations in Microsoft Academic
Google Scholar™

Altmetrics

Downloads

38 downloads since deposited on 18 Feb 2011
24 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Endocrinology, Diabetes and Metabolism
Life Sciences > Endocrinology
Language:English
Date:2010
Deposited On:18 Feb 2011 13:03
Last Modified:30 Jul 2020 00:53
Publisher:Kurtis - Italian Society of Endocrinology
ISSN:0391-4097
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1007/bf03346683
PubMed ID:20190554

Download

Green Open Access

Download PDF  'Defects of steroidogenesis'.
Preview
Content: Published Version
Language: English
Filetype: PDF (Nationallizenzen 142-005)
Size: 230kB
View at publisher