Green, S M; Roback, M G; Krauss, B; Brown, L; McGlone, R G; Agrawal, D; McKee, M; Weiss, M; Pitetti, R D; Hostetler, M A; Wathen, J E; Treston, G; Garcia Pena, B M; Gerber, A C; Losek, J D; Oktay, C; Saetta, J P; Holloway, V; Heinz, P; Bleiberg, A H; Herd, D; Godambe, S A; Pershad, J; Luhmann, J D; Kennedy, R M; Dachs, R J; Priestley, S J; Acworth, J P (2010). Anticholinergics and ketamine sedation in children: a secondary analysis of atropine versus glycopyrrolate. Academic Emergency Medicine, 17(2):157-162.
This secondary analysis unexpectedly found that the coadministered anticholinergic atropine exhibited a superior adverse event profile to glycopyrrolate during ketamine sedation. Any such advantage requires confirmation in a separate trial; however, our data cast doubt on the traditional premise that glycopyrrolate might be superior. Further, neither anticholinergic showed efficacy in decreasing airway and respiratory adverse events.
This secondary analysis unexpectedly found that the coadministered anticholinergic atropine exhibited a superior adverse event profile to glycopyrrolate during ketamine sedation. Any such advantage requires confirmation in a separate trial; however, our data cast doubt on the traditional premise that glycopyrrolate might be superior. Further, neither anticholinergic showed efficacy in decreasing airway and respiratory adverse events.
| Contributors: | Emergency Department Ketamine Meta-analysis Study Group |
|---|---|
| Item Type: | Journal Article, refereed, original work |
| Communities & Collections: | 04 Faculty of Medicine > University Children's Hospital Zurich > Clinic for Surgery |
| Dewey Decimal Classification: | 610 Medicine & health |
| Scopus Subject Areas: | Health Sciences > Emergency Medicine |
| Language: | English |
| Date: | 2010 |
| Deposited On: | 22 Feb 2011 09:09 |
| Last Modified: | 23 Jan 2022 18:39 |
| Publisher: | Wiley-Blackwell |
| ISSN: | 1069-6563 |
| OA Status: | Closed |
| Free access at: | Publisher DOI. An embargo period may apply. |
| Publisher DOI: | https://doi.org/10.1111/j.1553-2712.2009.00634.x |
| PubMed ID: | 20370745 |
Green, S M