Slope stability of steep rock walls in glacierised and permafrost-affected high-mountain regions is influenced by a number of different factors and processes. For an integral assessment of slope stability, a better understanding of the predisposing factors is particularly important, especially in view of rapid climate-related changes. This study introduces a methodical design that includes suitable methods and techniques for investigations of different predisposing factors in high-mountain rock walls. Current state-of-the-art techniques are reviewed, and their potential application for in situ and remote studies is assessed. A comprehensive array of analyses and modeling tools is presented, including data-acquisition methods and subsequent stability analyses. Based on two case studies of recent slope instabilities in the European Alps, the effective application and coupling of measurements, analyses, and modeling methods are shown.