Umbricht, D; Koller, R; Schmid, L; Skrabo, A; Grübel, C; Huber, T; Stassen, H (2003). How specific are deficits in mismatch negativity generation to schizophrenia? Biological Psychiatry, 53(12):1120-1131.
Mismatch negativity deficits, and by extension deficits in early cortical auditory information processing, appear to be specific to schizophrenia. Animal and human studies implicate dysfunctional N-methyl-D-aspartate receptor functioning in MMN deficits. Thus MMN deficits may become a useful endophenotype to investigate the genetic underpinnings of schizophrenia, particularly with regard to the N-methyl-D-aspartate receptor.
Mismatch negativity deficits, and by extension deficits in early cortical auditory information processing, appear to be specific to schizophrenia. Animal and human studies implicate dysfunctional N-methyl-D-aspartate receptor functioning in MMN deficits. Thus MMN deficits may become a useful endophenotype to investigate the genetic underpinnings of schizophrenia, particularly with regard to the N-methyl-D-aspartate receptor.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > Institute for Regenerative Medicine (IREM) |
| Dewey Decimal Classification: | 610 Medicine & health |
| Scopus Subject Areas: | Life Sciences > Biological Psychiatry |
| Language: | English |
| Date: | 2003 |
| Deposited On: | 08 Sep 2011 09:26 |
| Last Modified: | 06 Nov 2023 02:38 |
| Publisher: | Elsevier |
| ISSN: | 0006-3223 |
| OA Status: | Closed |
| Publisher DOI: | https://doi.org/10.1016/S0006-3223(02)01642-6 |
| PubMed ID: | 12814863 |
Umbricht, D