Header

UZH-Logo

Maintenance Infos

When proton pumps go sour: Urinary acidification and kidney stones


Wagner, C A (2008). When proton pumps go sour: Urinary acidification and kidney stones. Kidney International, 73(10):1103-1105.

Abstract

H(+)-ATPases mediate urinary acidification along the collecting duct, and mutations in their B1 and a4 subunits result in distal renal tubular acidosis. The pathomechanisms by which these mutations affect pump activity are only poorly understood. Common polymorphisms may impair pump activity and may link the pump to a higher risk for alkaline urine and the development of kidney stones.

Abstract

H(+)-ATPases mediate urinary acidification along the collecting duct, and mutations in their B1 and a4 subunits result in distal renal tubular acidosis. The pathomechanisms by which these mutations affect pump activity are only poorly understood. Common polymorphisms may impair pump activity and may link the pump to a higher risk for alkaline urine and the development of kidney stones.

Statistics

Citations

Dimensions.ai Metrics
4 citations in Web of Science®
5 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

71 downloads since deposited on 14 Nov 2008
6 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Center for Integrative Human Physiology
04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Health Sciences > Nephrology
Language:English
Date:May 2008
Deposited On:14 Nov 2008 17:39
Last Modified:24 Jun 2022 11:56
Publisher:Nature Publishing Group
ISSN:0085-2538
OA Status:Hybrid
Publisher DOI:https://doi.org/10.1038/ki.2008.137
PubMed ID:18449176
  • Content: Accepted Version