Abstract
This paper describes the development of a structural mimetic for the extracellular loops of a human GPCR. The three extracellular loops were grafted onto the scaffold of the E.coli outer membrane beta-barrel protein OmpA
Walser, R; Kleinschmidt, J H; Zerbe, O (2011). A chimeric GPCR model mimicking the ligand binding site of the human Y1 receptor studied by NMR spectroscopy. ChemBioChem, 12(11):1690-1693.
Abstract
This paper describes the development of a structural mimetic for the extracellular loops of a human GPCR. The three extracellular loops were grafted onto the scaffold of the E.coli outer membrane beta-barrel protein OmpA
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| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 07 Faculty of Science > Department of Chemistry |
| Dewey Decimal Classification: | 540 Chemistry |
| Scopus Subject Areas: | Life Sciences > Biochemistry
Life Sciences > Molecular Medicine Life Sciences > Molecular Biology Physical Sciences > Organic Chemistry |
| Uncontrolled Keywords: | mimetic, , GPCR, , NMR, , structural biology |
| Language: | English |
| Date: | 2011 |
| Deposited On: | 27 Oct 2011 14:24 |
| Last Modified: | 23 Jan 2022 19:23 |
| Publisher: | Wiley-Blackwell |
| ISSN: | 1439-4227 |
| OA Status: | Closed |
| Publisher DOI: | https://doi.org/10.1002/cbic.201100244 |
| PubMed ID: | 21695755 |
Walser, R