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Differential modulation of emotion processing brain regions by noradrenergic and serotonergic antidepressants


Brühl, Annette Beatrix; Jäncke, Lutz; Herwig, Uwe (2011). Differential modulation of emotion processing brain regions by noradrenergic and serotonergic antidepressants. Psychopharmacology, 216(3):389-399.

Abstract

The brain regions involved in the processing of negative emotional stimuli were differentially modulated by selective noradrenergic and serotonergic drugs: thalamic activity was increased by reboxetine, whereas citalopram primarily affected ventrolateral prefrontal regions. Thus, dysfunction in these regions, which could be identified in depressed patients, may predict treatment responses to either noradrenergic or serotonergic antidepressants.

Abstract

The brain regions involved in the processing of negative emotional stimuli were differentially modulated by selective noradrenergic and serotonergic drugs: thalamic activity was increased by reboxetine, whereas citalopram primarily affected ventrolateral prefrontal regions. Thus, dysfunction in these regions, which could be identified in depressed patients, may predict treatment responses to either noradrenergic or serotonergic antidepressants.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Clinical and Social Psychiatry Zurich West (former)
06 Faculty of Arts > Institute of Psychology
Dewey Decimal Classification:150 Psychology
610 Medicine & health
Scopus Subject Areas:Life Sciences > Pharmacology
Language:English
Date:2011
Deposited On:26 Oct 2011 10:15
Last Modified:16 Apr 2024 03:52
Publisher:Springer
ISSN:0033-3158
OA Status:Green
Publisher DOI:https://doi.org/10.1007/s00213-011-2227-2
PubMed ID:21359508
  • Content: Published Version
  • Language: English
  • Description: Nationallizenz 142-005