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Segregation analysis of overweight body condition in an experimental cat population


Häring, T; Wichert, Brigitta; Dolf, G; Haase, B (2011). Segregation analysis of overweight body condition in an experimental cat population. Journal of Heredity, 102:28-31.

Abstract

The goal of this study was to analyze the mode of inheritance of an overweight body condition in an experimental cat population. The cat population consisted of 95 cats of which 81 cats could be clearly classified into lean or overweight using the body condition scoring system according to Laflamme. The lean or overweight classification was then used for segregation analyses. Complex segregation analyses were employed to test for the significance of one environmental and 4 genetic models (general, mixed inheritance, major gene, and polygene). The general genetic model fit the data significantly better than the environmental model (P ≤ 0.0013). Among all other models employed, the major gene model explained the segregation of the overweight phenotype best. This is the first study in which a genetic component could be shown to be responsible for the development of overweight in cats.

Abstract

The goal of this study was to analyze the mode of inheritance of an overweight body condition in an experimental cat population. The cat population consisted of 95 cats of which 81 cats could be clearly classified into lean or overweight using the body condition scoring system according to Laflamme. The lean or overweight classification was then used for segregation analyses. Complex segregation analyses were employed to test for the significance of one environmental and 4 genetic models (general, mixed inheritance, major gene, and polygene). The general genetic model fit the data significantly better than the environmental model (P ≤ 0.0013). Among all other models employed, the major gene model explained the segregation of the overweight phenotype best. This is the first study in which a genetic component could be shown to be responsible for the development of overweight in cats.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Animal Nutrition
Dewey Decimal Classification:570 Life sciences; biology
630 Agriculture
Language:English
Date:2011
Deposited On:04 Nov 2011 07:49
Last Modified:20 Sep 2018 03:24
Publisher:Oxford University Press
ISSN:0022-1503
OA Status:Green
Publisher DOI:https://doi.org/10.1093/jhered/esr029
PubMed ID:21846744

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