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Sirolimus therapy for angiomyolipoma in tuberous sclerosis and sporadic lymphangioleiomyomatosis: a phase 2 trial


Davies, D M; de Vries, P J; Johnson, S R; McCartney, D L; Cox, J A; Serra, A L; Watson, P C; Howe, C J; Doyle, T; Pointon, K; Cross, J J; Tattersfield, A E; Kingswood, J C; Sampson, J R (2011). Sirolimus therapy for angiomyolipoma in tuberous sclerosis and sporadic lymphangioleiomyomatosis: a phase 2 trial. Clinical Cancer Research, 17(12):4071-4081.

Abstract

This study showed sustained regression of renal angiomyolipomas in patients with tuberous sclerosis or sporadic LAM receiving 2 years of sirolimus treatment. Possible effects on pulmonary function and neurocognition require further investigation.

Abstract

This study showed sustained regression of renal angiomyolipomas in patients with tuberous sclerosis or sporadic LAM receiving 2 years of sirolimus treatment. Possible effects on pulmonary function and neurocognition require further investigation.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Nephrology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Oncology
Life Sciences > Cancer Research
Language:English
Date:2011
Deposited On:07 Dec 2011 12:23
Last Modified:30 Jul 2020 02:13
Publisher:American Association for Cancer Research
ISSN:1078-0432
OA Status:Hybrid
Publisher DOI:https://doi.org/10.1158/1078-0432.CCR-11-0445
PubMed ID:21525172

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