Bianchi, M; Niemiec, M J; Siler, U; Urban, C F; Reichenbach, J (2011). Restoration of anti-Aspergillus defense by neutrophil extracellular traps in human chronic granulomatous disease after gene therapy is calprotectin-dependent. Journal of Allergy and Clinical Immunology, 127(5):1243-1252.
Reconstituted NET formation by GT for human CGD was associated with rapid cure of pre-existing therapy-refractory invasive pulmonary aspergillosis in vivo, underlining the role of functional NADPH oxidase in NET formation and calprotectin release for antifungal activity. These results demonstrate the critical role of calprotectin in human innate immune defense against Aspergillus infection.
Reconstituted NET formation by GT for human CGD was associated with rapid cure of pre-existing therapy-refractory invasive pulmonary aspergillosis in vivo, underlining the role of functional NADPH oxidase in NET formation and calprotectin release for antifungal activity. These results demonstrate the critical role of calprotectin in human innate immune defense against Aspergillus infection.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic |
| Dewey Decimal Classification: | 610 Medicine & health |
| Scopus Subject Areas: | Health Sciences > Immunology and Allergy
Life Sciences > Immunology |
| Language: | English |
| Date: | 2011 |
| Deposited On: | 16 Dec 2011 14:21 |
| Last Modified: | 23 Jan 2022 19:46 |
| Publisher: | Elsevier |
| ISSN: | 0091-6749 |
| OA Status: | Closed |
| Free access at: | Publisher DOI. An embargo period may apply. |
| Publisher DOI: | https://doi.org/10.1016/j.jaci.2011.01.021 |
| PubMed ID: | 21376380 |
Bianchi, M