Wu, L; Drinkel, E; Gaggia, F; Capolicchio, S; Linden, Anthony; Falivene, L; Cavallo, L; Dorta, R (2011). Room-temperature synthesis of tetra-ortho-Substituted biaryls by NHC-catalyzed Suzuki-Miyaura couplings. Chemistry - A European Journal, 17(46):12886-12890.
Into the groove: The introduction of a C2‐symmetric N‐heterocyclic carbene ligand with appropriately substituted naphthyl side chains enables the efficient Suzuki–Miyaura coupling to form bulky tetra‐ortho‐substituted biaryls from aryl bromides and chlorides at room temperature. DFT calculations uncover the subtle steric phenomena at play that lead to the superior catalytic performance. Cyoct=cyclooctyl.
Into the groove: The introduction of a C2‐symmetric N‐heterocyclic carbene ligand with appropriately substituted naphthyl side chains enables the efficient Suzuki–Miyaura coupling to form bulky tetra‐ortho‐substituted biaryls from aryl bromides and chlorides at room temperature. DFT calculations uncover the subtle steric phenomena at play that lead to the superior catalytic performance. Cyoct=cyclooctyl.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 07 Faculty of Science > Department of Chemistry |
| Dewey Decimal Classification: | 540 Chemistry |
| Scopus Subject Areas: | Physical Sciences > Catalysis
Physical Sciences > Organic Chemistry |
| Uncontrolled Keywords: | biaryls · cross-coupling · N-heterocyclic carbene, , ligand · palladium |
| Language: | English |
| Date: | 2011 |
| Deposited On: | 07 Dec 2011 13:18 |
| Last Modified: | 07 Dec 2023 02:38 |
| Publisher: | Wiley-Blackwell |
| ISSN: | 0947-6539 |
| Funders: | Alfred Werner Foundation, SNF, Roche Research Foundation |
| OA Status: | Closed |
| Publisher DOI: | https://doi.org/10.1002/chem.201102442 |
| PubMed ID: | 21984486 |
| Project Information: |
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Wu, L