Yonekawa, K; Neidhart, M; Altwegg, L A; Wyss, C A; Corti, R; Vogl, T; Grigorian, M; Gay, S; Lüscher, T F; Maier, W (2011). Myeloid related proteins activate toll-like receptor 4 in human acute coronary syndromes. Atherosclerosis, 218(2):486-492.
In ACS, MRP8 and MRP8/14 complex are specific ligands of TLR4, which induce the release of TNFα and probably other pro-inflammatory agents from monocytes. This specific MRP8/14-dependent pathway with striking similarities to sepsis increasing expression of TLR4 in thrombi appears to be involved in the pathogenesis of coronary occlusion and may represent a novel therapeutic target in ACS.
In ACS, MRP8 and MRP8/14 complex are specific ligands of TLR4, which induce the release of TNFα and probably other pro-inflammatory agents from monocytes. This specific MRP8/14-dependent pathway with striking similarities to sepsis increasing expression of TLR4 in thrombi appears to be involved in the pathogenesis of coronary occlusion and may represent a novel therapeutic target in ACS.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > University Hospital Zurich > Rheumatology Clinic and Institute of Physical Medicine
04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiology |
| Dewey Decimal Classification: | 610 Medicine & health |
| Scopus Subject Areas: | Health Sciences > Cardiology and Cardiovascular Medicine |
| Language: | English |
| Date: | 2011 |
| Deposited On: | 06 Jan 2012 14:20 |
| Last Modified: | 30 Jul 2020 02:29 |
| Publisher: | Elsevier |
| ISSN: | 0021-9150 |
| OA Status: | Closed |
| Publisher DOI: | https://doi.org/10.1016/j.atherosclerosis.2011.06.020 |
| PubMed ID: | 21782178 |
| Project Information: |
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Yonekawa, K