Navigation auf zora.uzh.ch

Search ZORA

ZORA (Zurich Open Repository and Archive)

DDOS: due to massive botnet requests against our ‘Advanced Search’ we have restricted access to UZH (local and VPN). Thank you for your understanding.

Haemoglobin, oxygen carriers and perioperative organ perfusion

Kocian, R; Spahn, D R (2008). Haemoglobin, oxygen carriers and perioperative organ perfusion. Best Practice & Research: Clinical Anaesthesiology, 22(1):63-80.

Abstract

Under normal conditions, only 20-30% of the delivered oxygen is metabolised. In normovolaemic anaemia, the organism reacts with increases in cardiac output and oxygen extraction. Once these mechanisms are exceeded, allogeneic blood transfusions may be administered. However, such transfusions are associated with serious adverse effects and alternatives such as artificial oxygen carriers are being sought. The main groups of artificial oxygen carriers are extracellular haemoglobin solutions and perfluorocarbons. Preparations undergoing experimental and clinical assessment include Human Polymerized Haemoglobin (Polyheme), Polymerized Bovine Haemoglobin-based Oxygen Carrier (HBOC-201, Hemopure), Haemoglobin Raffimer (HemoLink), Diaspirin Cross-linked Haemoglobin (HemAssist), Human Recombinant Haemoglobin (rHb), Enzyme Cross-linked Poly-haemoglobin, Maleimide-activated Polyethylene-glycol Modified Haemoglobin (MP4, Hemospan), Zero-linked Haemoglobin (ZL-HbBv) and Recombinant Hybrid of Human-alpha-chains and Bovine-beta-chains and Perflubron (Oxygent). Research into some of these compounds has been discontinued, while others have advanced into clinical phase III trials, but none has achieved market approval for Europe, US or Canada so far.

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Anesthesiology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Anesthesiology and Pain Medicine
Language:English
Date:2008
Deposited On:04 Dec 2008 08:36
Last Modified:02 Apr 2025 03:46
Publisher:Elsevier
ISSN:1753-3740
OA Status:Green
Publisher DOI:https://doi.org/10.1016/j.bpa.2007.10.003
PubMed ID:18494389
Download PDF  'Haemoglobin, oxygen carriers and perioperative organ perfusion'.
Preview
  • Content: Accepted Version

Metadata Export

Statistics

Citations

Dimensions.ai Metrics

Altmetrics

Downloads

305 downloads since deposited on 04 Dec 2008
40 downloads since 12 months
Detailed statistics

Authors, Affiliations, Collaborations

Similar Publications