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A Brief Account of Rho GTPases in Retinal Physiology and Pathophysiology


Heynen, S R; Ogunshola, O O; Grimm, C (2012). A Brief Account of Rho GTPases in Retinal Physiology and Pathophysiology. In: LaVail, M M; Ash, J D; Anderson, R E; Hollyfield, J G; Grimm, C. Retinal Degenerative Diseases. New York, NY: Springer, 581-587.

Abstract

Rho GTPases are a class of proteins with pleiotropic cellular functions. RAS-related C3 botulinum substrate 1 (RAC1), cell division cycle 42 homolog (CDC42), and ras homolog gene family member A (RHOA) are three classical small GTPases and their role in the modulation of the cellular cytoskeleton has been intensely studied. Cytoskeletal modulations are important processes in cellular movement and neuronal growth cone dynamics. Recent work has shown that Rho GTPases are also involved in other cellular processes including development and apoptosis. This chapter will give a short overview of the role of Rho GTPases in the retina.

Abstract

Rho GTPases are a class of proteins with pleiotropic cellular functions. RAS-related C3 botulinum substrate 1 (RAC1), cell division cycle 42 homolog (CDC42), and ras homolog gene family member A (RHOA) are three classical small GTPases and their role in the modulation of the cellular cytoskeleton has been intensely studied. Cytoskeletal modulations are important processes in cellular movement and neuronal growth cone dynamics. Recent work has shown that Rho GTPases are also involved in other cellular processes including development and apoptosis. This chapter will give a short overview of the role of Rho GTPases in the retina.

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Item Type:Book Section, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Ophthalmology Clinic
04 Faculty of Medicine > Center for Integrative Human Physiology
05 Vetsuisse Faculty > Institute of Veterinary Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Life Sciences > General Biochemistry, Genetics and Molecular Biology
Language:English
Date:2012
Deposited On:20 Mar 2012 16:05
Last Modified:03 Nov 2022 15:40
Publisher:Springer
Series Name:Advances in Experimental Medicine and Biology
Number:723
ISSN:0065-2598
ISBN:978-1-4614-0630-3
OA Status:Closed
Publisher DOI:https://doi.org/10.1007/978-1-4614-0631-0_74
PubMed ID:22183381