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Diabetes mellitus and survival in cystic fibrosis patients after lung transplantation


Hofer, M; Schmid, C; Benden, C; Speich, R; Inci, I; Weder, W; Boehler, A (2012). Diabetes mellitus and survival in cystic fibrosis patients after lung transplantation. Journal of Cystic Fibrosis, 11(2):131-136.

Abstract

BACKGROUND: Diabetes mellitus (DM) is common in CF and associated with more severe disease. It is unclear whether DM influences outcome of lung transplantation (LTx). METHODS: One hundred twenty-three CF patients evaluated for LTx at our centre were included. Survival was calculated. RESULTS: Patients with and without DM did not differ with regard to gender, age, FEV(1) and BMI prior to LTx. Eighty patients (65%) had a diagnosis of DM before and 13 (11%) only after LTx. Recipients with DM had a significantly higher 1- and 5-year survival (89% and 71%) than those without (71% and 51%). In the multivariate Cox-regression analysis, DM had no impact on LTx-survival. CONCLUSIONS: One- and five-year survival rates after LTx tend to be better in CF recipients with DM compared to those without DM. No impact of DM on the development of BOS was found.

Abstract

BACKGROUND: Diabetes mellitus (DM) is common in CF and associated with more severe disease. It is unclear whether DM influences outcome of lung transplantation (LTx). METHODS: One hundred twenty-three CF patients evaluated for LTx at our centre were included. Survival was calculated. RESULTS: Patients with and without DM did not differ with regard to gender, age, FEV(1) and BMI prior to LTx. Eighty patients (65%) had a diagnosis of DM before and 13 (11%) only after LTx. Recipients with DM had a significantly higher 1- and 5-year survival (89% and 71%) than those without (71% and 51%). In the multivariate Cox-regression analysis, DM had no impact on LTx-survival. CONCLUSIONS: One- and five-year survival rates after LTx tend to be better in CF recipients with DM compared to those without DM. No impact of DM on the development of BOS was found.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic and Policlinic for Internal Medicine
04 Faculty of Medicine > University Hospital Zurich > Clinic for Pneumology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Endocrinology and Diabetology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Pediatrics, Perinatology and Child Health
Health Sciences > Pulmonary and Respiratory Medicine
Language:English
Date:2012
Deposited On:13 Jan 2012 20:15
Last Modified:11 Mar 2020 22:26
Publisher:Elsevier
ISSN:1569-1993
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.jcf.2011.10.005
PubMed ID:22112935

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