We study the constraints on the Lee-Wick Higgs sector arising from direct collider searches. We work in an effective-field theory framework, where all of the Lee-Wick partners are integrated out, with the sole exception of the Lee-Wick Higgs bosons. The resulting theory is a two-Higgs doublet model where the second doublet has wrong-sign kinetic and mass terms. We include the bounds coming from direct Higgs searches at both LEP and Tevatron using the code HiggsBounds, and show the currently excluded parameter space. We also analyze the prospects of LHC Run-I, finding that with a total integrated luminosity of 5fb-1 and a center-of-mass energy of 7 TeV, most of the parameter space for the standard model-like CP-even Higgs will be probed.