OBJECTIVE: To experimentally evaluate three different contrast injection protocols at thoraco-abdominal high-pitch dual-source computed tomography angiography (CTA), with regard to level and homogeneity of vascular enhancement at different cardiac outputs. MATERIALS AND METHODS: A uniphasic, a biphasic as well as an individually tailored contrast protocol were tested using a human vascular phantom. Each protocol was scanned at 5 different cardiac outputs (3-5L/min, steps of 0.5L/min) using an extracorporeal cardiac pump. Vascular enhancement of the thoraco-abdominal aorta was measured every 5cm. Overall mean enhancement of each protocol and mean enhancement for each cardiac output within each protocol were calculated. Enhancement homogeneity along the z-axis was evaluated for each cardiac output and protocol. RESULTS: Overall mean enhancement was significantly higher in the uniphasic than in the other two protocols (all p<.05), whereas the difference between the biphasic and tailored protocol was not significant (p=.76). Mean enhancement among each of the 5 cardiac outputs within each protocol was significantly different (all p<.05). Only within the tailored protocol mean enhancement differed not significantly at cardiac outputs of 3.5L/min vs. 5L/min (484±25HU vs. 476±19HU, p=.14) and 4 vs. 5L/min (443±49HU vs. 476±19HU, p=.05). Both, uniphasic and tailored protocol yielded homogenous enhancement at all cardiac outputs, whereas the biphasic protocol failed to achieve homogenous enhancement. CONCLUSION: This phantom study suggests that diagnostic and homogenous enhancement at thoraco-abdominal high-pitch dual-source CTA is feasible with either a uniphasic or an individually tailored contrast protocol.