Zinkernagel, A S; Hruz, P; Uchiyama, S; von Köckritz-Blickwede, M; Schuepbach, R A; Hayashi, T; Carson, D A; Nizet, V (2012). Importance of toll-like receptor 9 in host defense against M1T1 Group A Streptococcus infections. Journal of Innate Immunity, 4(2):213-218.
Timely recognition and elimination of invasive group A Streptococcus (GAS) by innate immunity is crucial to control infection. The intracellular pattern recognition receptor Toll-like receptor 9 (TLR9) promotes macrophage hypoxia-inducible factor-1α levels, oxidative burst and nitric oxide production in response to GAS. TLR9 contributes to GAS clearance in vivo in both localized cutaneous and systemic infection models.
Timely recognition and elimination of invasive group A Streptococcus (GAS) by innate immunity is crucial to control infection. The intracellular pattern recognition receptor Toll-like receptor 9 (TLR9) promotes macrophage hypoxia-inducible factor-1α levels, oxidative burst and nitric oxide production in response to GAS. TLR9 contributes to GAS clearance in vivo in both localized cutaneous and systemic infection models.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > University Hospital Zurich > Division of Surgical Research
04 Faculty of Medicine > University Hospital Zurich > Institute of Intensive Care Medicine 04 Faculty of Medicine > University Hospital Zurich > Clinic for Infectious Diseases |
| Dewey Decimal Classification: | 610 Medicine & health |
| Language: | English |
| Date: | 2012 |
| Deposited On: | 21 Jan 2012 10:37 |
| Last Modified: | 21 Sep 2018 07:04 |
| Publisher: | Karger |
| ISSN: | 1662-811X |
| OA Status: | Green |
| Free access at: | PubMed ID. An embargo period may apply. |
| Publisher DOI: | https://doi.org/10.1159/000329550 |
| PubMed ID: | 21860217 |
Zinkernagel, A S