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Multicentric Castleman's disease as a cause for unclear febrile episodes in a 55-year-old HIV-infected man


Lederer, H; Achermann, Y; Tinguely, M; Stenner, F; Fehr, J (2012). Multicentric Castleman's disease as a cause for unclear febrile episodes in a 55-year-old HIV-infected man. Infection, 40(2):203-205.

Abstract

Our case illustrates the difficulties involved in diagnosing multicentric Castleman's disease (MCD) in a human immunodeficiency virus-infected man with febrile episodes and malaise. In the absence of well-established treatment protocols, we have chosen a new treatment algorithm with rituximab, etoposide, and valganciclovir, which led to the remission of clinical symptoms. Yet, we advocate focused exploration for MCD in immunosuppressed patients with unclear febrile episodes, as recent advances in treatment are promising.

Abstract

Our case illustrates the difficulties involved in diagnosing multicentric Castleman's disease (MCD) in a human immunodeficiency virus-infected man with febrile episodes and malaise. In the absence of well-established treatment protocols, we have chosen a new treatment algorithm with rituximab, etoposide, and valganciclovir, which led to the remission of clinical symptoms. Yet, we advocate focused exploration for MCD in immunosuppressed patients with unclear febrile episodes, as recent advances in treatment are promising.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic and Policlinic for Internal Medicine
04 Faculty of Medicine > University Hospital Zurich > Institute of Pathology and Molecular Pathology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Infectious Diseases
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2012
Deposited On:21 Jan 2012 18:58
Last Modified:21 Sep 2018 14:32
Publisher:Springer
ISSN:0300-8126
OA Status:Green
Publisher DOI:https://doi.org/10.1007/s15010-011-0174-9
PubMed ID:21837451

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