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Valli, Isabel; Stone, James; Mechelli, Andrea; Bhattacharyya, Sagnik; Raffin, Marie; Allen, Paul; Fusar-Poli, Paolo; Lythgoe, David; O'Gorman, Ruth; Seal, Marc; McGuire, Philip (2011). Altered medial temporal activation related to local glutamate levels in subjects with prodromal signs of psychosis. Biological Psychiatry, 69(1):97-9.
In individuals at high risk of psychosis, medial temporal dysfunction seemed related to a loss of the normal relationship with local glutamate levels. This study provides the first evidence that links medial temporal dysfunction with the central glutamate system in humans and is consistent with evidence that drugs that modulate glutamatergic transmission might be useful in the treatment of psychosis.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic |
| Dewey Decimal Classification: | 610 Medicine & health |
| Scopus Subject Areas: | Life Sciences > Biological Psychiatry |
| Language: | English |
| Date: | 2011 |
| Deposited On: | 22 Feb 2012 15:19 |
| Last Modified: | 06 Jan 2025 03:01 |
| Publisher: | Elsevier |
| ISSN: | 0006-3223 |
| OA Status: | Green |
| Publisher DOI: | https://doi.org/10.1016/j.biopsych.2010.08.033 |
| PubMed ID: | 21035785 |
Valli, Isabel