Mloston, G; Pieczonka, A M; Korany, A A; Linden, A; Heimgartner, H (2012). A new approach to morpholin-2-one derivatives via the reaction of β-amino alcohols with dicyanofumarates. ARKIVOC, 2012(iii):181-192.
A novel approach for the synthesis of morpholin-2-one derivatives from dialkyl dicyanofumarates and β-amino alcohols is presented. The reaction takes place under mild conditions via an addition-elimination-lactonization pathway. The formation of the six- membered ring occurs selectively leading to a single diastereomer. In contrast to arylhydrazines, the reaction of hydrazine hydrate with dicyanofumarates yields pyrazol-3(2H)-ones and not 5-aminopyrazoles.
A novel approach for the synthesis of morpholin-2-one derivatives from dialkyl dicyanofumarates and β-amino alcohols is presented. The reaction takes place under mild conditions via an addition-elimination-lactonization pathway. The formation of the six- membered ring occurs selectively leading to a single diastereomer. In contrast to arylhydrazines, the reaction of hydrazine hydrate with dicyanofumarates yields pyrazol-3(2H)-ones and not 5-aminopyrazoles.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 07 Faculty of Science > Department of Chemistry |
| Dewey Decimal Classification: | 540 Chemistry |
| Language: | English |
| Date: | 23 January 2012 |
| Deposited On: | 02 Apr 2012 07:20 |
| Last Modified: | 04 Dec 2018 15:07 |
| Publisher: | Arkat USA Inc |
| ISSN: | 1551-7004 |
| Funders: | European Social Fund ‘HUMAN – BEST INVESTMENT!’ |
| OA Status: | Green |
| Official URL: | http://www.arkat-usa.org/get-file/42701 |
Mloston, G