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New staging system and a registry for perihilar cholangiocarcinoma

DeOliveira, Michelle L; Schulick, R D; Nimura, Y; Rosen, C; Gores, G; Neuhaus, P; Clavien, P A (2011). New staging system and a registry for perihilar cholangiocarcinoma. Hepatology, 53(4):1363-1371.

Abstract

Perihilar cholangiocarcinoma is one of the most challenging diseases with poor overall survival. The major problem for anyone trying to convincingly compare studies among centers or over time is the lack of a reliable staging system. The most commonly used system is the Bismuth-Corlette classification of bile duct involvement, which, however, does not include crucial information such as vascular encasement and distant metastases. Other systems are rarely used because they do not provide several key pieces of information guiding therapy. Therefore, we have designed a new system reporting the size of the tumor, the extent of the disease in the biliary system, the involvement of the hepatic artery and portal vein, the involvement of lymph nodes, distant metastases, and the volume of the putative remnant liver after resection. The aim of this system is the standardization of the reporting of perihilar cholangiocarcinoma so that relevant information regarding resectability, indications for liver transplantation, and prognosis can be provided. With this tool, we have created a new registry enabling every center to prospectively enter data on their patients with hilar cholangiocarcinoma (www.cholangioca.org). The availability of such standardized and multicenter data will enable us to identify the critical criteria guiding therapy.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Visceral and Transplantation Surgery
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Hepatology
Language:English
Date:2011
Deposited On:02 Mar 2012 22:40
Last Modified:06 Nov 2024 02:41
Publisher:Wiley-Blackwell
ISSN:0270-9139
Additional Information:Comment in: Nat Rev Gastroenterol Hepatol. 2011 May;8(5):252-253.
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/hep.24227
PubMed ID:21480336
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