In the 21st century human life has been profoundly changed by developments in sanitation, medical interventions and public health measures. Practically every person born into a developed nation population has a chance to survive throughout entire reproductive life and well beyond. Human body has evolved in the past adaptations to hunting-gathering, and later, agricultural ways of life. In the new situation of practically non-existent premature mortality and technologically developed complex societies medical practice will devote less attention to "saving lives"--preventing premature deaths--and more to enhancing capacities of our biological organisms and providing for maintenance of the bodies beyond their biological limits established by evolution. The role of advances in nanotechnology, information technology, neuroscience and biotechnology is discussed in the context of mind and body enhancements.