Blenn, C; Wyrsch, P; Althaus, F R (2011). The ups and downs of tannins as inhibitors of poly(ADP-ribose)glycohydrolase. Molecules, 16(2):1854-1877.
DNA damage to cells activates nuclear poly(ADP-ribose)polymerases (PARPs) and the poly(ADP-ribose) (PAR) synthesized is rapidly cleaved into ADP-ribose (ADPR) by PAR glycohydrolase (PARG) action. Naturally appearing tannin-like molecules have been implicated in specific inhibition of the PARG enzyme. This review deals with the in vitro and in vivo effects of tannins on PAR metabolism and their downstream actions in DNA damage signaling.
DNA damage to cells activates nuclear poly(ADP-ribose)polymerases (PARPs) and the poly(ADP-ribose) (PAR) synthesized is rapidly cleaved into ADP-ribose (ADPR) by PAR glycohydrolase (PARG) action. Naturally appearing tannin-like molecules have been implicated in specific inhibition of the PARG enzyme. This review deals with the in vitro and in vivo effects of tannins on PAR metabolism and their downstream actions in DNA damage signaling.
| Item Type: | Journal Article, refereed, further contribution |
|---|---|
| Communities & Collections: | 05 Vetsuisse Faculty > Institute of Veterinary Pharmacology and Toxicology |
| Dewey Decimal Classification: | 570 Life sciences; biology |
| Scopus Subject Areas: | Physical Sciences > Analytical Chemistry
Physical Sciences > Chemistry (miscellaneous) Life Sciences > Molecular Medicine Life Sciences > Pharmaceutical Science Life Sciences > Drug Discovery Physical Sciences > Physical and Theoretical Chemistry Physical Sciences > Organic Chemistry |
| Language: | English |
| Date: | 2011 |
| Deposited On: | 28 Feb 2012 07:53 |
| Last Modified: | 23 Jan 2022 20:50 |
| Publisher: | MDPI Publishing |
| ISSN: | 1420-3049 |
| OA Status: | Gold |
| Free access at: | PubMed ID. An embargo period may apply. |
| Publisher DOI: | https://doi.org/10.3390/molecules16021854 |
| PubMed ID: | 21343889 |
Blenn, C