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Response inhibition or salience detection in the right ventrolateral prefrontal cortex?

Walther, S; Friederich, H C; Stippich, C; Weisbrod, M; Kaiser, S (2011). Response inhibition or salience detection in the right ventrolateral prefrontal cortex? NeuroReport, 22(15):778-782.

Abstract

This study addresses the question of whether frontal activation in response-inhibition tasks is specifically associated with the suppression of a motor response. An alternative model suggests a role in the detection of behaviorally relevant or salient events. For this purpose, we used functional MRI with an auditory go/no-go paradigm. This paradigm allowed the disentangling of inhibition-related from salience-related effects, which were associated with different frontal regions. Importantly, the right ventrolateral prefrontal cortex consistently showed sensitivity for salience but not for inhibition requirements. This reflects a more general salience-detection mechanism, which is not specific for response-inhibition tasks.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Clinical and Social Psychiatry Zurich West (former)
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > General Neuroscience
Language:English
Date:2011
Deposited On:09 Mar 2012 09:51
Last Modified:06 Feb 2025 02:40
Publisher:Lippincott Wiliams & Wilkins
ISSN:0959-4965
OA Status:Closed
Publisher DOI:https://doi.org/10.1097/WNR.0b013e32834af670
PubMed ID:21876462

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