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Resistance patterns with tyrosine kinase inhibitors in melanoma: new insights


Dummer, Reinhard; Flaherty, Keith T (2012). Resistance patterns with tyrosine kinase inhibitors in melanoma: new insights. Current Opinion in Oncology, 24(2):150-154.

Abstract

PURPOSE OF REVIEW:

After years of therapeutic approaches with limited effects in metastatic melanoma, new inhibitors of serine-threonine and tyrosine kinases have demonstrated impressive clinical efficacy and improved survival.
RECENT FINDINGS:

This review explains the molecular background for the development of specific kinase inhibitors and briefly summarizes their clinical impact on advanced melanoma.
SUMMARY:

Despite robust early clinical efficacy, the antiproliferative effect of these kinase inhibitors is limited. The resistance mechanisms are explored currently and will help to identify new targets for melanoma therapy.

Abstract

PURPOSE OF REVIEW:

After years of therapeutic approaches with limited effects in metastatic melanoma, new inhibitors of serine-threonine and tyrosine kinases have demonstrated impressive clinical efficacy and improved survival.
RECENT FINDINGS:

This review explains the molecular background for the development of specific kinase inhibitors and briefly summarizes their clinical impact on advanced melanoma.
SUMMARY:

Despite robust early clinical efficacy, the antiproliferative effect of these kinase inhibitors is limited. The resistance mechanisms are explored currently and will help to identify new targets for melanoma therapy.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2012
Deposited On:16 Apr 2012 06:43
Last Modified:23 Sep 2018 07:09
Publisher:Lippincott Wiliams & Wilkins
ISSN:1040-8746
OA Status:Closed
Publisher DOI:https://doi.org/10.1097/CCO.0b013e32834fca92
PubMed ID:22316627

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