Header

UZH-Logo

Maintenance Infos

Plasma atrial natriuretic peptide concentrations in horses with heart disease: A pilot study


Trachsel, Dagmar S; Grenacher, Beat; Weishaupt, Michael A; Schwarzwald, Colin C (2012). Plasma atrial natriuretic peptide concentrations in horses with heart disease: A pilot study. The Veterinary Journal, 192(2):166-170.

Abstract

Atrial natriuretic peptide (ANP) is a cardiovascular biomarker that might be useful in assessing the severity of cardiac disease in horses. Plasma ANP concentrations (Cp(ANP)) were compared between horses with heart disease but normal chamber size and function (Group A; n=6), horses with heart disease associated with left atrial (LA) enlargement, LA dysfunction, and/or left ventricular (LV) enlargement (Group B; n=5), and horses with no clinically apparent cardiovascular disease (Group C; n=13). The median (min-max) for Cp(ANP) was significantly higher in Group B (53.5 (36.0-70.7) pg/mL), compared to Group A (12.5 (6.3-19.8) pg/mL) and Group C (13.4 (7.2-34.0) pg/mL). Backwards stepwise multiple linear regression showed that Cp(ANP) in horses with heart disease was related to LA dimensions, but not to LV size, LA function, and LV function. The results indicated that Cp(ANP) in horses might be useful in detecting LA enlargement and that Cp(ANP) could be related to the severity of cardiac disease. Larger prospective studies are necessary to confirm these results.

Abstract

Atrial natriuretic peptide (ANP) is a cardiovascular biomarker that might be useful in assessing the severity of cardiac disease in horses. Plasma ANP concentrations (Cp(ANP)) were compared between horses with heart disease but normal chamber size and function (Group A; n=6), horses with heart disease associated with left atrial (LA) enlargement, LA dysfunction, and/or left ventricular (LV) enlargement (Group B; n=5), and horses with no clinically apparent cardiovascular disease (Group C; n=13). The median (min-max) for Cp(ANP) was significantly higher in Group B (53.5 (36.0-70.7) pg/mL), compared to Group A (12.5 (6.3-19.8) pg/mL) and Group C (13.4 (7.2-34.0) pg/mL). Backwards stepwise multiple linear regression showed that Cp(ANP) in horses with heart disease was related to LA dimensions, but not to LV size, LA function, and LV function. The results indicated that Cp(ANP) in horses might be useful in detecting LA enlargement and that Cp(ANP) could be related to the severity of cardiac disease. Larger prospective studies are necessary to confirm these results.

Statistics

Citations

Dimensions.ai Metrics
17 citations in Web of Science®
18 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

155 downloads since deposited on 22 Mar 2012
45 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Equine Department
Dewey Decimal Classification:570 Life sciences; biology
630 Agriculture
Scopus Subject Areas:Life Sciences > Animal Science and Zoology
Health Sciences > General Veterinary
Language:English
Date:2012
Deposited On:22 Mar 2012 07:59
Last Modified:11 Dec 2020 18:19
Publisher:Elsevier
ISSN:1090-0233
OA Status:Green
Publisher DOI:https://doi.org/10.1016/j.tvjl.2011.06.035
PubMed ID:21782487

Download

Green Open Access

Download PDF  'Plasma atrial natriuretic peptide concentrations in horses with heart disease: A pilot study'.
Preview
Filetype: PDF
Size: 397kB
View at publisher