Does collaborative knowledge production in intercultural teams of researchers from the global North and South offer ways to avoid ‘Western’ dominance in globalised science? This is the key question examined in the present article, which draws on experiences from the international development research network of the Swiss National Centre of Competence in Research (NCCR) North-South. The article illustrates what has been done to bring together ‘Western’ and ‘non-Western’ research traditions and rationalities in development research and provides insights into the opportunities and constraints of intercultural, collaborative knowledge production. It reveals a critical awareness of the potential, limitations, and consequences of methodological inclusiveness. Although collaborative knowledge production processes involve challenges and large investments, they offer an alternative to the dominant aspirations of individualistic leadership and scientific excellence. Collaboration plays a critical role in the development of scientific creativity in general, and in the context of sustainable development in particular.