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Fitness cost of SCCmec and methicillin resistance levels in Staphylococcus aureus


Ender, Miriam; McCallum, Nadine; Adhikari, Rajan; Berger-Bächi, Brigitte (2004). Fitness cost of SCCmec and methicillin resistance levels in Staphylococcus aureus. Antimicrobial Agents and Chemotherapy, 48(6):2295-2297.

Abstract

Transformation of a type I SCCmec element into Staphylococcus aureus yielded highly oxacillin-resistant transformants with a reduced growth rate. Faster-growing variants could again be selected at the cost of reduced resistance levels, demonstrating an inverse correlation between oxacillin resistance levels and growth rate.

Abstract

Transformation of a type I SCCmec element into Staphylococcus aureus yielded highly oxacillin-resistant transformants with a reduced growth rate. Faster-growing variants could again be selected at the cost of reduced resistance levels, demonstrating an inverse correlation between oxacillin resistance levels and growth rate.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Medical Microbiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2004
Deposited On:06 Aug 2012 16:09
Last Modified:23 Sep 2018 07:19
Publisher:American Society for Microbiology (ASM)
ISSN:0066-4804
OA Status:Closed
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1128/AAC.48.6.2295-2297.2004
PubMed ID:15155238

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