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Mnohocetné endokrinni neoplazie u psa - kazuistika


Kolevska, J; Vlach, D; Hrabeta, J; Novotny, L; Pospischil, Andreas (2012). Mnohocetné endokrinni neoplazie u psa - kazuistika. Veterinářství, 62(1):16-20.

Abstract

Multiple endocrine neoplasia (MEN) embodies a group of diseases in human patients and domestic animals that are characterized by neoplasia of two or more endocrine tissues. In humans, MEN is grouped into three major syndromes: MEN-1, MEN2A, and MEN-2B. MEN-1 is an autosomal dominant hereditary syndrome resulting from the mutation of the menin gne, which codes for a protein involved in transcription inhibition. The various mutations identified in the menin gene sequence of patients with MEN-1 have indicated correlation with development of different tumor phenotypes. MEN-like syndromes in dogs, cats, horses, bulls, and ferrets have been reported. The presented case report described a simultaneous occurrence of malignant insulinoma and thyroid adenocarcinoma in a seven-year-old, female Irish Setter with the episodes of weakness and collapses.

Abstract

Multiple endocrine neoplasia (MEN) embodies a group of diseases in human patients and domestic animals that are characterized by neoplasia of two or more endocrine tissues. In humans, MEN is grouped into three major syndromes: MEN-1, MEN2A, and MEN-2B. MEN-1 is an autosomal dominant hereditary syndrome resulting from the mutation of the menin gne, which codes for a protein involved in transcription inhibition. The various mutations identified in the menin gene sequence of patients with MEN-1 have indicated correlation with development of different tumor phenotypes. MEN-like syndromes in dogs, cats, horses, bulls, and ferrets have been reported. The presented case report described a simultaneous occurrence of malignant insulinoma and thyroid adenocarcinoma in a seven-year-old, female Irish Setter with the episodes of weakness and collapses.

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Additional indexing

Other titles:Multiple endocrine neoplasia in a dog
Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Pathology
Dewey Decimal Classification:570 Life sciences; biology
Language:Czech
Date:2012
Deposited On:11 Sep 2012 13:36
Last Modified:16 Feb 2018 23:48
Publisher:Statní zemědělské nakladatelství
ISSN:0506-8231
OA Status:Green
Related URLs:http://www.vetweb.cz/ (Publisher)

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