The 10(th) International Adenovirus Meeting was held at Umea (June 13-17 2012), organized by G. Wadell, N. Arnberg and K. Isaksson. It gathered almost 140 scientists from Europe, North and South America, Asia and Australia. The meeting gave an overview of the state of the art of adenovirus research. Here, we highlight the advances in molecular and cell biology of adenoviruses, in particular virus structure and entry, replication, pathology and immunology, evolution and tropism of vectors. We conclude with an outlook into future developments in the field.