This study determined the discoloration of five CAD/CAM resins, four manually polymerized resins, and glass-ceramic as control group. Specimens were divided into three groups (N=300, n=30) to be stored in coffee, black tea and red wine (n=10). The discoloration was measured using a spectrophotometer after 1, 7, 29, 90, 180 days storage. All tested groups showed color change (ΔE) at all time points. The manually polymerized resin composites GD (Gradia) and CM (CronMix K), and the CAD/CAM resin composite HC (Blanc High-class) showed significantly higher ΔE compared to all other groups in all tested media. The discoloration was extrinsic and decreased after polishing for the majority of the tested materials. Except CAD/CAM resin HC (Blanc High-class), all CAD/CAM resins showed similar color stability compared to the control group.