# Post-Protein-Binding Reactivity and Modifications of the fac-Re(CO)(3)](+) Core

Zobi, Fabio; Spingler, Bernhard (2012). Post-Protein-Binding Reactivity and Modifications of the fac-Re(CO)(3)](+) Core. Inorganic Chemistry, 51(3):1210-1212.

## Abstract

The reactivity of the Re(CO)(3)(H2O)(2)](+) complex coordinated to the His15 residue of HEW lysozyme is described. In the fully metalated protein (Lys-1), the Re ion retains its reactivity only toward selected ligands, while others induce a ligand-mediated demetalation of the enzyme. It is further shown that some of the complexes that may be engineered'' on the lysozyme do not react with the free protein even if present in solution in excess. The formation of stable metal adducts starting from Lys-1 was confirmed by X-ray crystallography.

## Abstract

The reactivity of the Re(CO)(3)(H2O)(2)](+) complex coordinated to the His15 residue of HEW lysozyme is described. In the fully metalated protein (Lys-1), the Re ion retains its reactivity only toward selected ligands, while others induce a ligand-mediated demetalation of the enzyme. It is further shown that some of the complexes that may be engineered'' on the lysozyme do not react with the free protein even if present in solution in excess. The formation of stable metal adducts starting from Lys-1 was confirmed by X-ray crystallography.

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