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Neutralism and selectionism: a network-based reconciliation

Wagner, A (2008). Neutralism and selectionism: a network-based reconciliation. Nature Reviews. Genetics, 9(12):965-974.

Abstract

Neutralism and selectionism are extremes of an explanatory spectrum for understanding patterns of molecular evolution and the emergence of evolutionary innovation. Although recent genome-scale data from protein-coding genes argue against neutralism, molecular engineering and protein evolution data argue that neutral mutations and mutational robustness are important for evolutionary innovation. Here I propose a reconciliation in which neutral mutations prepare the ground for later evolutionary adaptation. Key to this perspective is an explicit understanding of molecular phenotypes that has only become accessible in recent years.

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Department of Biochemistry
07 Faculty of Science > Department of Biochemistry

Special Collections > SystemsX.ch
Special Collections > SystemsX.ch > Research, Technology and Development Projects > YeastX
Dewey Decimal Classification:570 Life sciences; biology
Scopus Subject Areas:Life Sciences > Molecular Biology
Life Sciences > Genetics
Health Sciences > Genetics (clinical)
Language:English
Date:2008
Deposited On:11 Dec 2008 08:17
Last Modified:03 Jul 2025 03:35
Publisher:Nature Publishing Group
ISSN:1471-0056
OA Status:Green
Publisher DOI:https://doi.org/10.1038/nrg2473
PubMed ID:18957969
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