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Meta-analysis of genome-wide linkage scans of attention deficit hyperactivity disorder

Zhou, K; et al; Steinhausen, H C (2008). Meta-analysis of genome-wide linkage scans of attention deficit hyperactivity disorder. American Journal of Medical Genetics. Part B, 147B(8):1392-1398.

Abstract

Genetic contribution to the development of attention deficit hyperactivity disorder (ADHD) is well established. Seven independent genome-wide linkage scans have been performed to map loci that increase the risk for ADHD. Although significant linkage signals were identified in some of the studies, there has been limited replications between the various independent datasets. The current study gathered the results from all seven of the ADHD linkage scans and performed a Genome Scan Meta Analysis (GSMA) to identify the genomic region with most consistent linkage evidence across the studies. Genome-wide significant linkage (P(SR) = 0.00034, P(OR) = 0.04) was identified on chromosome 16 between 64 and 83 Mb. In addition there are nine other genomic regions from the GSMA showing nominal or suggestive evidence of linkage. All these linkage results may be informative and focus the search for novel ADHD susceptibility genes.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Child and Adolescent Psychiatry
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Genetics (clinical)
Health Sciences > Psychiatry and Mental Health
Life Sciences > Cellular and Molecular Neuroscience
Uncontrolled Keywords:Genetics(clinical), Cellular and Molecular Neuroscience, Psychiatry and Mental health
Language:English
Date:5 December 2008
Deposited On:12 Dec 2008 10:48
Last Modified:03 Jul 2025 03:35
Publisher:Wiley-Blackwell
ISSN:1552-4841
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/ajmg.b.30878
PubMed ID:18988193

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