Burckhardt, C J; Greber, U F (2008). Redox rescues virus from ER trap. Nature Cell Biology, 10(1):9-11.
How viruses manage to resist physical and chemical stress and yet open their protective coats during cell infection has been a longstanding, fundamental question. A study with the DNA tumour virus SV40 now shows that protein folding and quality-control factors of the endoplasmic reticulum reshuffle disulfide bonds within the viral capsid, providing a molecular mechanism for the exit of infectious virions from the endoplasmic reticulum.
How viruses manage to resist physical and chemical stress and yet open their protective coats during cell infection has been a longstanding, fundamental question. A study with the DNA tumour virus SV40 now shows that protein folding and quality-control factors of the endoplasmic reticulum reshuffle disulfide bonds within the viral capsid, providing a molecular mechanism for the exit of infectious virions from the endoplasmic reticulum.
| Item Type: | Journal Article, refereed, further contribution |
|---|---|
| Communities & Collections: | 07 Faculty of Science > Institute of Molecular Life Sciences |
| Dewey Decimal Classification: | 570 Life sciences; biology |
| Language: | English |
| Date: | January 2008 |
| Deposited On: | 11 Feb 2008 12:17 |
| Last Modified: | 18 Feb 2018 09:24 |
| Publisher: | Nature Publishing Group |
| ISSN: | 1465-7392 |
| OA Status: | Green |
| Publisher DOI: | https://doi.org/10.1038/ncb0108-9 |
| PubMed ID: | 18172426 |
Burckhardt, C J