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Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy

Abstract

Studies of psychiatric disorders have traditionally focused on emotional symptoms such as depression, anxiety and hallucinations. However, poorly controlled cognitive deficits are equally prominent and severely compromise quality of life, including social and professional integration. Consequently, intensive efforts are being made to characterize the cellular and cerebral circuits underpinning cognitive function, define the nature and causes of cognitive impairment in psychiatric disorders and identify more effective treatments. Successful development will depend on rigorous validation in animal models as well as in patients, including measures of real-world cognitive functioning. This article critically discusses these issues, highlighting the challenges and opportunities for improving cognition in individuals suffering from psychiatric disorders.

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Brain Research Institute
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Life Sciences > Pharmacology
Life Sciences > Drug Discovery
Language:English
Date:2012
Deposited On:21 Feb 2013 14:25
Last Modified:25 Oct 2024 03:36
Publisher:Nature Publishing Group
ISSN:1474-1776
OA Status:Closed
Publisher DOI:https://doi.org/10.1038/nrd3628
PubMed ID:22293568
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