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Synthesis of stable peptide nucleic acid-modified gold nanoparticles and their assembly onto gold surfaces


Anstätt, Philipp; Zheng, Yuanhui; Thai, Thibaut; Funston, Alison M; Bach, Udo; Gasser, Gilles (2013). Synthesis of stable peptide nucleic acid-modified gold nanoparticles and their assembly onto gold surfaces. Angewandte Chemie Internationale Edition, 52(15):4217-4200.

Abstract

PNA does it better: Peptide nucleic acid (PNA) oligomers were attached to gold nanoparticles (AuNPs) through a variety of mono- and trithiol linkers. These functionalized particles had sufficient stability for sequence-specific self-assembly onto gold surfaces (see figure) in the absence of ions or surfactants. The nanoparticle surface densities obtained were superior to comparable DNA-modified AuNPs.

Abstract

PNA does it better: Peptide nucleic acid (PNA) oligomers were attached to gold nanoparticles (AuNPs) through a variety of mono- and trithiol linkers. These functionalized particles had sufficient stability for sequence-specific self-assembly onto gold surfaces (see figure) in the absence of ions or surfactants. The nanoparticle surface densities obtained were superior to comparable DNA-modified AuNPs.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Scopus Subject Areas:Physical Sciences > Catalysis
Physical Sciences > General Chemistry
Language:English
Date:2013
Deposited On:12 Apr 2013 07:12
Last Modified:24 Jan 2022 00:49
Publisher:Wiley-VCH Verlag
ISSN:1433-7851
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/anie.201209684
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